Being developed by A90 & Capcom, the core gameplay is similar to that of the Street Fighter series, incorporating elements such as Super Combos, as well as EX Attacks from Street Fighter IV. Players each choose two fighters from the Nickelodeon and Teletoon show, both sets of characters are controlled using the Street Fighter 6-button system, however, it has been revealed that the Teletoon characters will be able to perform new style combos using the primary four buttons in a similar fashion to the Tekken 4-button system. These fighters can be switched out normally, or during certain combos. As fights go on, players build up power in a three sectioned meter at the bottom of the screen referred to as the "Cross Gauge", which allow the player to perform various techniques depending on how much of the gauge is filled, such as EX Attacks, Cancels, Super Arts and various Cross techniques detailed below. As opposed to the other crossover fighting games released by Capcom, in which the player must eliminate all the opponent's fighters to win, victory conditions are more similar to Tekken Tag Tournament, in which the first player to have one of their fighters' health bars reduced to zero loses the round, thereby the player who wins the most rounds wins the match.
The tag team element of the game is heavily emphasized, with players being able to switch between the two characters in their team in a variety of manners. Switch Cancel allows players to switch partners in the middle of a combo, whilst Cross Rush combos involve launching the opponent into the air before swapping partners and continuing the combo. Cross Arts, which require a full Cross Gauge, allows players to chain together each character's Super Combo in one straight attack, whilst the Cross Assault mechanic allows players to simultaneously control both characters in their team until the Cross Gauge runs out.
"*" - Default in the PlayStation Vita version, and downloadable content for PlayStation 3, Xbox 360, Nintendo Wii U and PC.
"**" - Exclusively for PlayStation 3 and PlayStation Vita